Naphazoline

  • Naphazoline
  • 2 - (1 -naphthylmethyl ) -4,5- dihydroimidazole (IUPAC)
  • 2 - (1 -naphthylmethyl ) imidazoline
  • Naphazoline (Latin )
  • 835-31-4
  • 550-99-2 (hydrochloride)
  • 5144-52-5 ( nitrate)

R01AA08 R01AB02 S01GA01

Sympathomimetic

α1 -adrenoceptor agonist

  • 210.27 g.mol -1
  • 246.74 g.mol -1 (hydrochloride)
  • 273.29 g · mol -1 ( nitrate)

255-260 ° C ( hydrochloride)

Naphazoline hydrochloride:

Naphazoline hydrochloride:

  • Soluble in water:
  • 400 g · l -1 ( 25 ° C)
  • 170 g · l -1 ( 20 ° C)
  • Soluble in ethanol
  • Low solubility in chloroform
  • Insoluble in benzene and ether

Risk

  • 62 mg · kg -1 ( LD50, mouse, ip)
  • 170 mg · kg -1 ( LD50, mouse, i.v.)
  • 270 mg · kg -1 ( LD50, mouse, oral)
  • 514 mg · kg -1 ( LD50, mouse, s.c )
  • 0.8 mg · kg -1 ( LD50, Rabbit, i.v.)
  • 0.95 mg · kg -1 ( LD50, Rabbit, s.c )
  • 385 mg · kg -1 ( LD50, rat, s.c )
  • 13.2 mg · kg -1 ( LD50, mouse, iv, naphazoline hydrochloride )
  • 265 mg · kg -1 ( LD50, Mouse, oral, naphazoline hydrochloride )
  • 1260 mg · kg -1 ( LD50, Rat, oral, naphazoline hydrochloride )

Template: Infobox chemical / molecular formula search available

Naphazoline is a chemical compound that acts schleimhautabschwellend and blood vessel narrowing. It is used as a drug to reduce swelling in non-specific or allergic inflammation of the conjunctiva, or nasal mucosa as well as for decongestant for diagnostic purposes. Naphazoline is applied locally.

Pharmacology

Naphazoline is a sympathomimetic and acts on α - adrenergic receptors of the sympathetic nervous system, the vasoconstriction of the blood vessels with resultant decongestant mainly comes through α1 - agonism about. The effect on β -adrenoceptors is weak. The schleimhautabschwellende effect occurs after a few minutes and lasts 4 to 6 hours.

Clinical information

Areas of application

Naphazoline is displayed for decongestant use in non-infectious and allergic conjunctivitis and rhinitis, and sinusitis. In order to facilitate the implementation of specific diagnostic techniques ( rhinoscopy, cystoscopy ), the application of naphazoline is also displayed.

Side effects

As adverse effects can often ( 1-10 % of patients) an increased mucosal blood flow at the application site (blood wealth, reactive hyperemia), mucosal burning and dryness of mucous membranes occur. Prolonged use of the nasal mucosa, there is the risk of lengthy nose blockages (rhinitis medicamentosa, " drug sniffing ").

Overdose

Systemic effects may occur mainly in overdose and manifest itself in the form of, for example, nausea, fever, seizures, changes in heart rate, changes in blood pressure (hypertension, hypotension ) and respiratory disorders. Particularly when children the risk of overdose with significant effects on the central nervous system. Prolonged use or misuse it comes to the so-called privinismus.

Chemical and pharmaceutical information

Naphazoline is not verschreibungspflichig. Can be used medicinally, the highly water-soluble naphazoline hydrochloride or moderately water-soluble naphazoline nitrate.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Intraperitoneal injection Active ingredient Mucous membrane of nose Rhinoscope Perfusion
592297
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