Neprilysin

  • OMIM: 120520
  • UniProt: P08473
  • MGI: 97004
  • CAS Number: 82707-54-8

Neprilysin is a common enzyme in the human body, especially in the kidneys and lungs. In human brain, it will degrade the β -amyloid protein, which in its insoluble form deposits on the brain cells, and thus destroys it causes Alzheimer's disease. Therefore neprilysin is examined as a remedy for the disease, and it is a genetic defect responsible for the production of neprilysin gene suspected to increase the risk for Alzheimer's.

Neprilysin (also NEP, CALLA, enkephalinase, CD10 or neutral endopeptidase called ) is a zinc (II )-dependent membrane-bound metalloprotease and is involved in various processes of signal peptides, which play out in Alzheimer's and cancer, and high blood pressure a role. Neprilysin is involved in the degradation of opioid peptides such as Met- and Leu- enkephalins, and the degradation of ANF.

Human Genome Organisation Mouse Genome Informatics CAS registry number MEROPS Organism Amyloidosis Atrial natriuretic peptide Digital Object Identifier
308827
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