Pentetic acid

  • Diethylenetriaminepentaacetic acid
  • N, N -bis (2 - ( bis (carboxymethyl ) amino ) ethyl ) glycine
  • 3 -aza- 3-( carboxymethyl) - pentamethylendinitrilotetraessigsäure

White solid

Fixed

1.56 g · cm -3

220 ° C

Soluble in water (4.8 g · l-1 at 25 ° C)

Attention

587 mg · kg -1 ( LD50, rat, ip)

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Diethylenetriaminepentaacetic acid ( DTPA ) is a fünfprotonige acid and chemically related to EDTA. It is used as a chelating complex.

The excellent complexing properties especially for metal cations with large ionic radius DTPA predestined for use in medicine. For example, it is used in chelation therapy to detoxify after accidents with heavy metals and in particular for the transport of gadolinium as a contrast agent ( gadopentetate dimeglumine ) in the MR environment.

Production and representation

DTPA can be obtained by reaction of diethylene triamine with five equivalents of bromoacetic acid.

CAS registry number PubChem Dangerous Substances Directive (67/548/EEC) Intraperitoneal injection Contrast medium
236872
de