Phosphoribosylaminoimidazole carboxylase

The multifunctional protein ADE2 (gene name: PAICS ) is an enzyme found in vertebrates, wherein the two different enzymatic domains are fused to a protein: the Phosphoribosylaminoimidazol carboxylase ( AIRC ) and Phosphoribosylaminoimidazolsuccinocarboxamid synthase ( SAICAR synthase). These activities are part of purine biosynthesis and come in all living things before: as an individual enzymes in prokaryotes, fungi and plants, and as bifunctional enzymes in vertebrates.

Domains of the ADE2 catalyze the steps 6 and 7 of zehnschrittigen biosynthesis of IMP. The SAICAR synthase is inhibited by IMP or maleate. The human ADE2 complexed to the octamer.

Catalyzed reactions

AIRC

CO2

5 - Aminoimidazolribonukleotid (AIR) is carboxylated to 5 - aminoimidazole -4- carboxylatribonucleotid ( CAIR ).

SAICAR synthase

ATP ADP Pi

CAIR and aspartic acid are ligated with consumption of ATP.

Protein isoform Human Genome Organisation Lyase Ligase PROSITE Digital Object Identifier
29272
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