Since the age of 10, in the period from 1937 to 1947, he studied at the Paris Conservatoire, including with Nadia Boulanger, Felix Passerone and Olivier Messiaen.
Between 1949 and 1958, Henry worked at the Club d' Essai of the RTF studio, which had been founded by Pierre Schaeffer. In the years 1949-1950 Henry Schaeffer composed together with the symphony pour un homme seul. The premiere on March 18, 1950 created a stir because Henry in the École Normale de Musique de Paris a work without score presented along with Pierre Schaeffer and Jacques Poulin, which has been using electronic transfer of records and consisted only of sound collages. This day is considered as the birth of musique concrète.
In 1958, Henry left the RTF and in 1960 founded with Jean Baronnet the first private electronic studio in France.
Henry has composed since 1952 in addition to ballet and film music. He worked with, among others, the choreographer Maurice Béjart and Alwin Nikolais. His most successful work is the Messe pour le temps présent from the year 1967. Psyché Skirt With this exhibition he turned for the first time in rock music to this song was later edited to the theme song of the series Futurama. In Ceremony of 1969 he worked with the group Spooky Tooth.
Pierre Henry influenced not only the new music in the second half of the 20th century, but he is next Karlheinz Stockhausen as one of the " fathers" of techno music.
For the 2006 constructed tram in Mulhouse Henry created custom theme songs for the station announcements.