Pocket protein family

The pocket protein family is a family of proteins that act as tumor suppressors. The name derives from a binding pocket (english pocket ), with which they can bind their target molecules. They play an important role in the cell cycle by interacting with transcription factors of the E2F family and are regulated by their expression and phosphorylation. You may also be bound by a number of viral oncogenes, which may explain their role in carcinogenesis.

The pocket protein family in humans consists of three proteins:

• RB - retinoblastoma protein
• P107 - Retinoblastoma - like protein 1
• P130 - Retinoblastoma -like protein 2