Procarbazine

  • IUPAC: N- isopropyl -4 -(2- methylhydrazine Omethyl ) benzamide
  • Latin: Procarbazinum

L01XB01

Cytostatic

223-226 ° C ( monohydrochloride )

6.8 ( monohydrochloride )

614 mg · kg -1 ( LD50, mouse, ip)

Template: Infobox chemical / molecular formula search available

Procarbazine (trade name: Natulan ®) is a chemotherapy drug that belongs to the group of alkylating agents. It is a prodrug that is converted in Azoprocarbazin. The metabolic pathway is hepatic and in the erythrocytes.

The drug is used, among other things, for the treatment of Hodgkin's disease, non-Hodgkin's lymphoma, cerebral neoplasms and in a particular form of lung cancer, small-cell lung cancer.

Common side effects include the emergence of a lack of white blood cells ( leukocytes) and platelets (thrombocytes), so-called leukopenia or thrombocytopenia. Moreover, it may inter alia, to nausea, vomiting, sterility, and sensory disturbances.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Intraperitoneal injection Alkylating antineoplastic agent Active ingredient
661852
de