Prostacyclinsynthase

• OMIM: 601 699
• UniProt: Q16647

Prostacyclin ( gene: PTGIS ) is the enzyme which catalyses the rearrangement of prostaglandin H2 by prostacyclin. This reaction is to convert the counter- weight by thromboxane A2, and also the reaction products are physiological antagonist. The synthase is present in vertebrates. In humans, it is as a membrane protein in all tissue types, but especially to be found in ovaries, heart, skeletal muscle, lung and prostate.

Prostacyclin is localized in the membrane of the endoplasmic reticulum on the inside and is connected by a fusion protein closely associated with the enzymes COX-1/COX-2. As an opponent of a thromboxane A2- thrombosis produced the prostacyclin synthase gene therapy is a target for the treatment of pulmonary hypertension.

Catalyzed reaction

⇒

Prostaglandin H2 to prostaglandin rearranged I2 ( prostacyclin ).

Other Features

Certain variants of prostacyclin were associated with severe cases of respiratory syncytial virus infection of Japanese children.

Regulation

Signal transduction of tretinoin on the retinoic acid receptor increased the expression of prostacyclin. Enzyme activity is inhibited by peroxynitrite, which is prevented by glutathione or vitamin C.