Prostate-specific membrane antigen

  • CAS Number: 111070-04-3

Prostate specific membrane antigen ( PSMA) (synonyms: Glutamatcarboxypeptidase II NAALADase I = N -acetyl-L -aspartyl -L- glutamatpeptidase I Folathydrolase I) is a membrane-bound glycoprotein. PSMA has the function of an enzyme. Is a carboxypeptidase that cleaves C-terminal of glutamic acid. In humans, the gene encoding PSMA gene is p11.12 on chromosome 11 locus.

Description

PSMA occurs on normal prostate cells and prostate cancer cells. Furthermore, it is found on cells of the neovasculature ( newly formed vessels) other solid tumor types. With the progression and metastasis degree the expression of PSMA increases. Due to the high specificity as a tumor marker it is an ideal target antigen for new therapies against prostate cancer dar. For diagnostic purposes PSMA -specific monoclonal antibodies for imaging techniques can be used.

The human PSMA consists of 750 amino acids. The unmodified polypeptide has a molecular mass of 84 kDa. Depending on the tissue type and species are subject to 10 to 30 % of post-translational modification. The molar mass is then typically at about 100 kDa.

CAS registry number Neovascularization Tumormarker Medical imaging Prostate-specific antigen Digital Object Identifier
269545
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