Pseudouridine

• Ψ ( short code )
• Psi - uridine
• 5 - Ribosyluracil
• β -D - pseudouridine
• 5 - ( β -D - ribofuranosyl ) uracil
• 5 - [ (2S, 3R, 4S, 5R ) -3,4- dihydroxy-5- (hydroxymethyl )-2- tetrahydrofuranyl ] -1H- pyrimidine-2 ,4 -dione

Fixed

220-221 ° C

Template: Infobox chemical / molecular formula search available

Pseudouridine (abbreviated by the Greek letter Psi, Ψ ) is a naturally occurring nucleoside. It consists of the β -D - ribofuranose (sugar) and the nucleobase uracil. Pseudouridine is an isomer of uridine.

History

Pseudouridine ( Ψ ) in the early 1950s was discovered as a first modified nucleoside and one of the most common modified nucleosides. It is used particularly in tRNA in the TΨC loop before.

Properties

Pseudouridine forms a base pair with adenosine.

Chemically, it is a C -glycoside, in which the β -D -ribose is linked to the C5 atom of the uracil ( uridine When, however, the ribose is linked to a nitrogen atom of uracil ).

Pseudouridine is formed after transcription ( posttranscriptional ) from uridine. This isomerization catalyze Ψ synthases, which is referred to in the literature as Pseudouridylation.