Pyritinol

N06BX02

Antidementia

216-217 ° C

Template: Infobox chemical / molecular formula search available

Pyritinol (trade name: Encephabol ®, produced by Merck KGaA ) is a drug which is used as an anti-dementia drug for the treatment of senile dementia.

Synthesis

The compound can be prepared in a three-step synthesis of pyridoxine. In the first step, the conversion of pyridoxine hydrochloride in concentrated hydrobromic acid to give the corresponding bromo compound is carried out. This is then reacted with potassium ethyl xanthogenate. The target compound is produced by the dimerization of the resulting xanthate in the presence of ammonia.

Pharmacokinetics

Pharmacologically effective the company resulting from the cleavage at the disulfide bridge pyridoxine radicals (vitamin B6). The elimination half -life is approximately 6 hours, at a range of 2.5 to 8 hours. The availability is over 80 %. After oral administration, the maximum effect is after about 30 to 60 minutes. The drug crosses the blood -brain barrier and accumulates in the gray matter. The active ingredient and which is also pharmacologically active metabolites and their conjugates are excreted within 24 to about 70 % through the kidneys to 5% with the faeces. There was observed no accumulation of pyritinol in the organism.