Pyrrolnitrin

3-chloro- 4-(3 -chloro-2 -nitrophenyl) -1H-pyrrole (IUPAC)

D01AA07

• Antibiotic
• Antifungal

124.5 ° C

Attention

• > 2000 mg · kg -1 ( LD50, rat, oral)
• 86 mg · kg -1 ( LD50, mouse, ip)

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Pyrrolnitrin is a chemical compound selected from the group of the pyrrole.

Use

Pyrrolnitrin is an antifungal effective antibiotic that has been isolated from the bacterium Pseudomonas pyrrocinia. It is effective against several types of pathogenic fungi, including:

• Trichophyton rubrum
• Trichophyton mentagrophytes
• Trichophyton tonsurans

(see Trichophyton )

• Microsporum audouini
• Epidermophyton floccosum
• Malassezia furfur

It blocks the electron transport between succinate or reduced NADH and coenzyme Q.

His application is topical ( local).