ROCK1

Rho kinase 1 ( Gen: ROCK1 ) is an enzyme that is activated by phosphorylation of a number of other enzymes, as soon as the small G- protein RhoA binding itself is received. It is therefore essential component of the signal transduction. Rho- kinase is involved in the regulation of various cell functions such as contraction of smooth muscle cells, the organization of the actin cytoskeleton, cell adhesion, cell migration, cytokinesis, cell proliferation and migration of inflammatory cells.

The Rho kinases have evolved over the two- page animals. In humans, the Rho- kinase 1 is in the cytoplasm, in the membrane of the Golgi apparatus and during the S phase located in the centrioles, and especially in platelets. Freshly formed Rho kinase 1 inhibits itself by binding of the catalytic center at the C-terminus. This inhibition is released by binding to Rho ( reversible) or by separation of the end ( irreversible). This separation is particularly catalyzes the cell death by the enzyme caspase -3, which eventually lead to the membrane bulges ( blebbing ).

Fasudil hydrochloride is a specific inhibitor of Rho kinase.

Swell

  • Protein kinase
  • Signal transduction
Human Genome Organisation Rho family of GTPases Smooth muscle tissue Digital Object Identifier
680601
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