RPI is the abbreviation for:
- Raspberry Pi, a credit card sized single board computer that is being developed by the Raspberry Pi Foundation
- Religion Pedagogical Institute
- Rensselaer Polytechnic Institute
- Requested Interval Package, with cyclic electronic data transmission, the required time between two telegrams.
- Retail Price Index, English for Retail Cost Index, see cost of living index
- Ribose -5 -phosphate isomerase, an enzyme
- The Röher Park Department of Psychosomatics in the world of work in Eschweiler