Sarcosine

  • Sarcosine
  • N- methyl glycine
  • Methylaminoacetic

Colorless, crystalline solid

Fixed

208 ° C

Decomposition: 212 ° C

Very well in water (1480 g · l-1 at 20 ° C)

-513.3 KJ / mol

Template: Infobox chemical / molecular formula search available

Sarcosine ( Abbr: Sar ) is a non - proteinogenic amino acid. It is derived from glycine, an intermediate stage of the amino acid metabolism and a peptide component of the antibiotic, actinomycin, the immunosuppressant cyclosporin and the angiotensin II receptor antagonist saralasin. They also can be found in muscle and other body tissues.

Intramolecular rearrangement may arise from sarcosine and alanine by glycine demethylation.

History

Sarcosine was first discovered by Justus von Liebig from the creatine broth isolated (Greek σάρξ, sarx = flesh ), where the naming results.

Medical Relevance

While the human urine usually contains no sarcosine, it is in the urine of patients with prostate cancer detected. Biomarkers may therefore be used for the diagnosis of prostate cancer. Here, between a benign prostatic hyperplasia ( benign enlargement of the prostate), and metastatic and non-metastatic prostate cancer can differ.

In addition, sarcosine showed at doses of 2 grams per day in combination with other antipsychotic drugs, with the exception of clozapine, a reduction in the typical symptoms of schizophrenia.

CAS registry number Dactinomycin Angiotensin#Angiotensin II Medical diagnosis CRC Handbook of Chemistry and Physics Digital Object Identifier Trimethylglycine Integrated Authority File
709365
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