Schizosaccharomyces pombe

Schizosaccharomyces pombe

Schizosaccharomyces pombe is a fission yeast ( engl. "fission yeast" ), that is a yeast that is not by budding ( budding ), but by dividing the cell into two halves ( "splitting " ) increased. It is a rod-shaped unicellular eukaryotes, which is commonly used in molecular and cellular biology as a model organism.

From East African millet beer Paul Lindner these isolated fission yeast in 1893. The name comes from the S. pombe Swahili word for beer ( pombe ). As a model organism in cell biology, it was introduced by Murdoch Mitchison in the 50s.

The British biochemist Paul Nurse received for his work on the cell cycle regulation in fission yeast in 2001 along with Leland H. Hartwell and Tim Hunt received the Nobel Prize in Physiology or Medicine.

The genomic DNA sequence of S. pombe was published in 2002. In 2006, Akihisa Matsuyama and colleagues published the subcellular localization of all proteins.

Comparison with the budding yeast Saccharomyces cerevisiae

• S. cerevisiae has ~ 5600 open reading frames, Sch. pombe has 4945
• S. cerevisiae has 16 chromosomes, Sch. pombe has three
• S. cerevisiae is normally diploid, while Sch. pombe is normally haploid
• S. cerevisiae is primarily in the G1 phase while Sch. pombe mainly in the G2 phase is.