Sertindole

1 - [2 - [4 - [5- chloro-1- (4- fluorophenyl) indol- 3-yl] piperidin- 1-yl] ethyl] imidazolidin- 2-one ( IUPAC)

N05AE03

Antipsychotics

Attention

410 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Sertindole (trade name Serdolect ®) is a drug which belongs to the group of atypical neuroleptics. It is used for the treatment of schizophrenia.

Sertindole was withdrawn in 1998 just 16 months after launch due to cardiac toxicity by the manufacturer Lundbeck, but in 2006 with obligations (especially ECG monitoring ) medication approved as the second choice again.

Pharmacological properties

The drug is characterized in vitro by a high affinity for D2, 5- HT2 and α1 - receptors. Sertindole also acts as FIASMA ( functional inhibitors of acid sphingomyelinase ).

Sertindole acts both for positive symptoms and for negative symptoms of schizophrenia. Extrapyramidal side effects should not be significant.