SLC25A1

Tricarboxylate carrier, or Citratcarrier (CIC, CTP ) is called the protein in the inner membrane of mitochondria, which enables the exchange of citric acid to malate or phosphoenolpyruvate ( PEP) through the mitochondrial membrane. It is a transport protein. CTP is part of the so-called citrate shuttle and gluconeogenesis, and thus essential for energy metabolism in eukaryotes. In humans it is mainly localized in the liver cells.

The catalyzed membrane transport is:

It is an antiport. This part of the transport Citratshuttle is electrically compensated by the transport of a proton by means of the pyruvate / H symporter.

This second transport is irreversible due to the potential of the inner membrane. A possible compensatory transport is obviously unknown.

The expression of CIC is regulated by epigenetic mechanisms.

Human Genome Organisation Mitochondrial carrier Membrane (disambiguation) Transportprotein Epigenetics Digital Object Identifier
190944
de