SLC25A3

The mitochondrial phosphate transporter (PIC, PTP), the protein in the mitochondrial membrane of eukaryotes, which catalyzes the transportation of phosphate ion from the cytosol into the mitochondria. It is part of the respiratory chain and is one of the mitochondrial carriers. The transport equation is:

Mutations in the SLC25A3 gene are the cause of a rare inherited disorder in which the newborns die within a year of cardiomyopathies and hyperacidity. Probably plays PiC also the main role in the pathogenesis of reperfusion injury after ischemia.

Further Reading

  • Iacobazzi V, Infantino V, Costanzo P, Izzo P, Palmieri F: Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and Their transcription factors. No Pt 3, November 2005, pp. 613-21. doi: 10.1042/BJ20050776. PMC: 1276962 (Free full text ).
  • Yamano K, Ishikawa D, Esaki M, Endo T: The phosphate carrier HAS to ability to be sorted to Either the TIM22 pathway or the Tim23 pathway for its import into yeast mitochondria .. In: J Biol Chem 280, No. 11, 2005, pp. 10011-17. doi: 10.1074/jbc.M413264200. PMID 15,644,337th
Protein isoform Human Genome Organisation Digital Object Identifier PubMed Central
576044
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