SPG11

• OMIM: 610844
• UniProt: Q96JI7

Spatacsin (English Spastic paraplegia 11 protein also briefly SPG11 ) is a protein. It is encoded by the SPG11 gene is localized in human chromosome 15 ( 15q21.1 ). Spatacsin is formed in the nervous system, particularly in the cerebellum, in the cerebral cortex and hippocampus. The function of the protein is still unclear.

Several mutations of the SPG11 gene are known. They lead to a sub-form of hereditary spastic paraplegia, autosomal recessive hereditary spastic paraplegia 11 ( SPG11 ).