Squalene monooxygenase

• OMIM: 602 019
• UniProt: Q14534

Squalene monooxygenase (SE) is the enzyme that catalyzes the oxidation ,3 -epoxide of squalene to squalene, S -2. This reaction takes place in eukaryotes and some bacteria; in animals, it is part of the cholesterol biosynthesis. In humans SE is localized in the microsomes.

Catalyzed reaction

AH2 O2 ⇔ A H2O

Squalene is oxidized ,3 -epoxide to S- squalene -2, the acceptor is dehydrated.