Streptokinase

  • CAS Number: 9002-01-1

The Streptokinase is an extracellular protein that is secreted by β -hemolytic streptococci in the nutrient medium. Streptokinase is essential for hemolysis by streptococci, but has in itself no enzymatic activity. This is achieved only by forming a complex with plasminogen activator, which catalyzes the conversion of plasminogen to plasmin. Plasmin in turn is also an enzyme and dissolves blood clots. This property is utilized in the medical field.

Production

After centrifugation of the bacteria can be purified streptokinase from the spent medium. Because of this simple cleaning method can streptokinase win inexpensive. During the first cleaning step of streptokinase and streptodornase which is precipitated. The mixture of both enzymes is marketed under the name varidase.

Use

  • Streptokinase is used among other things for cleaning blutverschmutztem surgical material ( eg catheters and endoscopes ), but also for wound treatment (removal of eschar ).
  • Streptokinase is used in acute myocardial infarction. Here streptokinase is injected in very high doses. Supporting supplied by infusion ( streptokinase plasminogen = anistreplase ) plasminogen. Within a few minutes, the blood clots in the heart dissolves. Because of the antigenic property of streptokinase there is a further therapy with urokinase human origin.
  • Streptokinase is also used in severe thrombosis.

One consequence of therapy with streptokinase, even at lower doses, is not possible: Streptokinase is no protein of human origin, ie Streptokinase represents an antigen, and the body is anti- streptokinase antibodies. Should then be administered streptokinase, may lead to anaphylactic shock. It can also be dangerous an application of streptokinase after a streptococcal infection.

Trade names

Streptase (D, CH)

Varidase (D, A)

CAS registry number Anatomical Therapeutic Chemical Classification System DrugBank National Center for Biotechnology Information The FASEB Journal
751702
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