Synthon

A synthon is a conceptual building block of retrosynthetic planning. The underlying concept was developed by EJ Corey.

Derivation

A synthon is a structural unit within a molecule is, the one synthesis step can be assigned. The reactive sites of the synthons are designated by the letters a to d for acceptor or donor.

Example

In planning the synthesis of phenylacetic acid, two synthons can by theoretical division of the target molecule to the PhCH2-/-COOH-Bindung be identified: a nucleophilic " -COOH " group and an electrophilic " PhCH2 " group. The two synthons need not necessarily exist as a real molecule fragments, but the synthetic equivalents of said synthon may be used in the reaction in order to reach the target molecule. In this case, the cyanide anion, the -COOH synthon while benzyl is the synthetic equivalent of the benzyl synthon. The synthetic route to phenylacetic acid determined by retrosynthetic analysis as follows:

Examples of synthons

  • :, ( D synthon )
  • :, ( D synthon )
  • Carboxylic acid (d - synthon, working up with )
  • C1 synthons - carbon dioxide, carbon monoxide, cyanide
  • C2 synthons - acetylene, acetaldehyde
  • - C2H4OH synthons - Ethylene oxide
  • Carbocation synthons - alkyl halide
  • Carbanion synthons - Grignard reagent, the organolithium compound, Substitutierte acetylides
Benzyl bromide Digital Object Identifier
758402
de