Tachykinin receptor

Tachykinin receptors, also neurokinin receptors or shortly called NK receptors are proteins on the surface membrane of cells in tissue animals, which are activated by endogenous messenger substances from the group of tachykinins. The three known human tachykinin receptors NK1, NK2 and NK3, have a selectivity for the tachykinins substance P, neurokinin A and neurokinin B, and are also found in other mammals. All known tachykinin receptors belong to the G protein-coupled receptors and activate a signal transduction cascade involving heterotrimeric G proteins Gq/11 type. Activation of tachykinin receptors plays an important role, inter alia, in the perception of pain. With Aprepitant a tachykinin -inflammatory drugs is used as an antiemetic.