Tetrahydromethanopterin

H4MPT

Template: Infobox chemical / molecular formula search available

Tetrahydromethanopterin ( THMPT, H4MPT ) is a coenzyme in methanogenesis. It has been discovered in various microorganisms, and there plays an important role in the metabolism of methyl groups. A modified form of THMPT is related ( with the 2- hydroxyglutaric bound glutamyl ) and also the more familiar tetrahydrofolic acid THMPT Tetrahydrosarcinapterin.

Properties

Tetrahydromethanopterin containing the methyl group, which is reduced in the course of methanogenesis, and then transferred to Coenzyme M.

Compared to tetrahydrofolate methyl THMPT is to reduce severe due to the lack of carbonyl group on the phenyl ring. The reduction is mediated by an iron- sulfur cluster- free hydrogenase.

In C1 metabolism N Formylmethanofuran are the C1 group to the N5 of the pteridine, whereby formyl THMPT formed. The formyl group to the cationic condensing methenyl - THMPT, which is subsequently reduced to methenyl - THMPT. Methylene- MPT is reduced by means of methylene THMPT reductase coenzyme F420 to methyl THMPT. Methyl- THMPT transfers the methyl group of the methyl coenzyme M THMPT: coenzyme M methyl transferase.