Tetrapropylammonium perruthenate

  • TPAP
  • TPAPR
  • Ley -Griffith reagent

Dark green solid

Fixed

160 ° C.

Risk

Template: Infobox chemical / molecular formula search available

Tetrapropylammonium ( TPAP or TPAPR ) is a chemical compound that is described by the formula ( C3H7 ) 4N RuO4. Sometimes referred to as Griffith Ley reagent, this compound is especially used in organic syntheses. The salt consisting of the tetrapropylammonium cation, and the anion perruthenate ( RuO 4, ruthenate (VII) ). Ruthenium tetroxide is a very aggressive oxidant, but one step reduced derivative RuO4 - is a mild oxidizing agent to convert alcohols to aldehydes.

Said oxidizing agent may also be used for the oxidation of primary alcohols to carboxylic acids. But a catalyst and a co-oxidant with the addition of two equivalents of water is needed. In this case, the alcohol to the aldehyde and this is then further oxidized to the carboxylic acid.

TPAP is expensive, but can be used in catalytic amounts. The catalytic cycle is maintained by the addition of stoichiometric co-oxidants such as N- methylmorpholine -N-oxide or molecular oxygen.

CAS registry number Dangerous Substances Directive (67/548/EEC) N-Methylmorpholine N-oxide Digital Object Identifier
766408
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