Thiazole

1,3-thiazol

Colorless to yellow liquid

Liquid

1.20 g · cm -3

117-118 ° C

2.44 ( the conjugate Acid BH , 20 ° C)

Slightly soluble in water, soluble in ethanol

From 1.5365 to 1.5395

Risk

983 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Thiazole is a chemical compound from the group of heterocyclic compounds or heteroaromatic. It consists of a five-membered ring composed of three carbon and the sulfur or nitrogen atom, which serves as the basic structure in many organic compounds derived. It is a colorless to pale yellow liquid with pyridinartigem odor. Substituted derivatives of thiazole are referred to as thiazoles. Its isomer is the Isothiazole (1,2- thiazole ), where the sulfur atom is adjacent to the nitrogen.

Production and representation

The implementation of monochloroacetaldehyde with thioformamide provides thiazole. The oxidation of substituted 3- thiazo (prepared by the reaction Asinger ) with elemental sulfur provides analog substituted thiazoles.

Properties

Physical Properties

Thiazole is miscible with water, alcohol and ether.

Chemical Properties

Thiazoles are a group of organic compounds (similar to the azoles ) containing thiazole as a functional group. For example, contain vitamin B1, penicillin, epothilone, and clomethiazole luciferins (which belong to the group of benzothiazoles ) thiazole or hydrogenated derivatives of thiazole as a structural element. Thiazoles can be represented by a Hurd - Mori reaction. Dyes of this group are indicated by a color index in the range 49000-49399. Thiazol- salts are used as catalysts in the Stetter reaction, and the benzoin condensation.

Use

Thiazole used as a starting material for the production of fungicides, pharmaceuticals, and dyes.