Thrombophilia

The thrombophilia ( altgr. Thrombos, lumps ' and phileein love ') or thrombophilia is a genetic condition or acquired predisposition to the formation of blood clots within blood vessels (thrombosis ) or embolism due to altered properties of blood cells, blood plasma, blood flow and / or vessel walls.

Undetectable the thrombophilia is, for example, by

  • Increased platelet or erythrocyte aggregation ( agglutination tendency of platelets and red blood cells),
  • Increased blood viscosity,
  • Increase in procoagulant or reduction of anticoagulant factors,
  • Disorders of fibrinolysis
  • Rheological disorders with arterial hyper - or hypo venous circulation

Also, local changes in blood vessels can lead to the formation of thrombi. Pathological changes of the vascular wall by atherosclerosis or inflammation can lead to the accumulation and aggregation of platelets and thus also to vessel occlusion. The disruption of blood flow at constrictions (stenoses ) reinforced this tendency to local thrombosis. ( The term thrombophilia but rather describes a general tendency to clot formation, independent of local factors. )

Some causes of thrombophilia ( inherited and / or acquired)

  • APC resistance (factor V Leiden mutation, rare factor V Cambridge )
  • G20210A prothrombin (factor II)
  • Antiphospholipid Antibody
  • Thrombotic thrombocytopenic purpura
  • Heparin - induced thrombocytopenia
  • Persistently elevated factor VIIIc
  • Mutations in the gene THBD
  • Disease in angiology
  • Disease in hematology and oncology
Activated protein C resistance Protein C deficiency Protein S deficiency Antithrombin Heparin-induced thrombocytopenia Thrombomodulin
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