Transcription factor II D

The transcription factor IID ( TFIID ) is a protein complex in the nucleus of eukaryotic cells, which is required for the transcription of almost all genes. In particular, TFIID ensures exact positioning when reading. TFIID is depending on the organism of up to two dozen individual proteins.

The complex is completed in front of the transcription, bind with its member TBP to the TATA box in the core promoter of the gene, or in the case that there are no TATA box is provided with one of the other proteins of the core promoter. TBP TATA - binding leads to a 80 -degree bending of the DNA, which allows for further binding of the transcription factor TFIIA.

Core members of TFIID, which occur in all vertebrates, are ( human gene / protein): TBP ( UniProt P20226 ), TAF1 ( UniProt P21675 ), TAF4 ( UniProt O00268 ), TAF4B ( UniProt Q92750 ), TaF5 ( UniProt Q15542 ), TAF6 ( UniProt P49848 ), TAF9 ( UniProt Q16594 ), TAF10 ( UniProt Q12962 ), TAF11 ( UniProt Q15544 ).