Trichostatin A

• [R- ( E, E) ] -7 - [ 4 - (dimethylamino ) phenyl ]-N- hydroxy-4 ,6-dimethyl- 7 -oxo -2 ,4- heptadienamid
• TSA

Fixed

Soluble in ethanol

Attention

Template: Infobox chemical / molecular formula search available

Trichostatin A ( TSA) is an effective antifungal antibiotic from the bacterium Streptomyces platensis and selectively blocks the class I and class II histone deacetylases (HDAC ) of mammals; but not HDAC class III / sirtuins.

TSA also blocked the eukaryotic cell cycle, during the beginning of cell division.

TSA can be used to influence gene expression by acetyl groups are removed to histones and as transcription factors access to previously sealed promoter sequences. As often histone deacetylases are active in cancer cells, activate the deactivated in body cells genes that trichostatin A has potential as a cancer treatment. A theory for the mechanism of action of TSA states that the antibiotic up-regulated the expression of apoptosis genes, thereby reducing the probability of survival of cancer cells. Other theories see the TSA as an inducer of cell differentiation, resulting in a growth arrest of the dedifferentiated otherwise and thus causes capable of dividing cancer cells.

In clinical trials, trichostatin A has so far been hardly used.