Triclocarban

• 3,4,4 '- trichlorocarbanilide
• TCC
• 3 - (4 -chlorophenyl ) -1 - ( 3,4- dichlorophenyl ) urea

White odorless powder

Fixed

254-256 ° C

• Practically insoluble in water (0.11 mg · l -1 at 20 ° C)
• Soluble in polyethylene glycol and acetone

Attention

• 3,600 mg · kg -1 ( LD50, rat, oral)
• 600 mg · kg -1 ( LD50, mouse, oral)

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Triclocarban is a chemical compound from the group of Carbanilidderivate.

Production and representation

Triclocarban can be obtained by reacting 3,4- dichloroaniline with 4- chlorophenyl isocyanate.

Properties

Triclocarban is a white odorless powder that is practically insoluble in water.

Use

Triclocarban is used as an antibacterial agent and a preservative in the liquid soap and deodorants. A study in 1999-2000 showed that triclocarban in 84% of soaps sold was included in the United States. In Europe, the maximum permitted concentration of 0.2% in cosmetic products ( Directive 76/768/EEC, Annex VI, part 1 n ° 23). The effect is due to the influence of the cell membranes of the bacteria.

Safety

Triclocarban can cause methemoglobinemia and should therefore not be used in neonates and infants. When used for a Vaginalhygiene Erythema multiforme may be induced.