Trimethylarsine

• Trimethylarsine
• TMA ( not unique, see TMA)

Colorless liquid

Liquid

1.133 g · cm -3

-87.3 ° C

52 ° C.

Insoluble in water

Risk

• 7870 mg · kg -1 ( LD50, mouse, oral)
• 90 mg · kg -1 ( LD50, mouse, i.v.)
• 6000 mg · kg -1 ( LC50, Mammalia, inh. )
• 20,500 ppm x 10 min ( LC50, mouse, inh. )

Template: Infobox chemical / molecular formula search available

Trimethylarsine designated by IUPAC as trimethylarsine, is a metalloid - organic compound with the structural formula ( CH3) 3As. It is an Arsenic, easily vaporized liquid substance whose odor is reminiscent of garlic. It was discovered in 1854.

Occurrence and toxicology

Trimethyl produced in bacteria and fungi through the reduction of arsenic ( V) compounds, with subsequent methylation. The metabolism of mammals is arsenic contrast to dimethylarsine compounds such as dimethylarsinic acid ( cacodylic also ) to which can be excreted in the urine. The outgoing of arsenic compounds lives are at risk based on the reaction with sulfur-containing proteins, the associated inhibition of the citric acid cycle and the disruption of the substrate chain phosphorylation in glycolysis.

History

Bartolomeo Gosio discovered that the fungus Scopulariopsis brevicaulis generated from rotting wallpaper with metal-containing pigments arsenic- containing gases. Leopold Gmelin and many other chemists then sat down and for a ban on arsenic-containing paints. The chemist Frederick Challenger identified the gas in 1932 as trimethyl arsine.

Assuming that trimethylarsine was responsible for the significant health effects of arsenic wallpapers seem to contradict recent toxicological studies, with the professional world is not here agree.