Uridine diphosphate

  • Uridine 5'- trihydrogendiphosphat
  • UDP

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Uridine diphosphate ( UDP short ) is a chemical compound from the group of nucleotides ( ribonucleotides ) which is derived from uridine. It is an ester of the diphosphoric acid with the nucleoside uridine and consists of a pyrophosphate, the sugar ribose and uracil nucleobase.

Biological Significance

Uridine diphosphate is the most important, mainly involved in carbohydrate metabolism uridine nucleotide and acts as a coenzyme in the glycosylation.

Uridine diphosphate is formed at a reaction catalyzed by glycogenin. This catalyzes the addition of glucose to itself by the first UDP -glucose formed from UTP and glucose, binds to the Tyr -194 residue of its active site, with uridine diphosphate is formed.

Glycogenin

UDP is also the starting material for the synthesis of dTTP ( deoxythymidine triphosphate ), which is needed for DNA synthesis. Here UDP is first converted by the enzyme ribonucleotide reductase dUDP. After dephosphorylation of dUMP this is by thymidylate synthase to dTMP methylated ( see figure at right). As a methyl group donor here acts N5, N10- methylenetetrahydrofolate. The resulting dTMP is phosphorylated to the triphosphate ( dTTP ), and can be used for DNA synthesis.

Related compounds

  • Uridine monophosphate
  • Uridine triphosphate
  • UDP-glucose
  • UDP-galactose
  • UDP -glucuronic acid
  • UDP glycogen synthase
CAS registry number PubChem Cofactor (biochemistry) Uridine diphosphate glucose
794554
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