Urs Jenal

Urs Jenal ( born December 31, 1961 in Alvaneu ) is a Swiss microbiologist and research at the Biozentrum, University of Basel.

Life

Urs Jenal studied Experimental Biology at the ETH Zurich and received his doctorate there in 1991. Subsequently, he completed post- doctorates at the ETH Zurich and Stanford University. Since 1996, researches and teaches Jenal at the Biozentrum, University of Basel, first as an assistant professor and since 2002 as a professor of molecular microbiology.

Work

Urs Jenal explored the molecular basis of signal transduction that controls the growth, development and behavior of bacteria. International attention was Jenal through his discovery of a new pathway, which is based on a new cyclic di - nucleotide (c- di -GMP) and the formation of microbial biofilms which coordinates and contributes to the development of chronic bacterial infections. In the model bacterium Caulobacter crescentus, he discovered that c- di-GMP controls the transition from motile bacteria to sedentary biofilm - forming mold and this process coordinated with the replication cycle of the cells. Recent work investigating the importance of c- di-GMP signaling network for chronic lung infections caused by Pseudomonas aeruginosa in patients with cystic fibrosis (cystic fibrosis).

Awards

  • 2011: Elected member of the American Academy of Microbiology (AAM )
  • 2012: Elected member of the European Molecular Biology Organization ( EMBO)

List of publications

  • Steiner, S., Lori, C. Boehm, A., Jenal, U. ( 2012) allosteric activation of exopolysaccharide synthesis through cyclic di-GMP -stimulated protein - protein interaction. EMBO J 2013 32 (3): 354-68; PMID 23202856
  • Malone, J. G., Jaeger, T., Manfredi, P,. Doetsch, A., Blanka, A., Bos, R., Cornelis, GR, Haeussler, S., Jenal, U. ( 2012) The signal transduction mechanism YfiBNR Reveals novel targets for the evolution of persistent Pseudomonas aeruginosa in cystic fibrosis airways. PLoS Pathogens 8 (6): e1002760; PMID 22719254
  • Abel, S. Chien, P., Wassmann, P. Schirmer, T., Kaever, V., Laub, MT, Baker, TA, and Jenal, U. ( 2011) Regulatory cohesion of cell cycle and cell differentiation through inter- linked phosphorylation and second messenger networks. Mol Cell, 43, 550 ( IF: 14,447 )
  • Malone, JG, Jaeger, T., Spangler, C., Ritz, D., Spang, A., Arrieumerlou, C., Kaever, V., Landmann, R. and Jenal, U. ( 2010). YfiBNR mediates cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa. PLoS Pathogens, 6 ( 3), e1000804.
  • Boehm, A., Kaiser, M., Li, H., Spangler, C., Kasper CA, Ackermann, M., Kaever, V., Sourjik, V., Roth, V. and Jenal, U. (2010 ). Second messenger mediated adjustment of bacterial swimming velocity. Cell, 141, 107
  • Duerig, A., Abel, S., Folcher, M., Nicollier, M., Schwede, T., Amiot, N., Giese, B. and Jenal, U. ( 2009). Second messenger -mediated spatiotemporal control of protein degradation Regulates bacterial cell cycle progression. Genes and Development, 23 ( 1), 93
  • Schirmer, T. and Jenal, U. ( 2009). Structural and mechanistic determinants of c- di-GMP signaling. Nature Rev Microbiol, 7: 724-735; PMID 19756011
  • Boehm, A., Steiner, S., Zaehringer, F., Casanova, A., Hamburger, F., Ritz, D., Keck, W., Ackermann, M., Schirmer, T. and Jenal, U. ( 2009). Second messenger signaling Governs Escherichia coli biofilm induction upon ribosomal stress. Mol Microbiol, 72 (6): 1500-1516; PMID 19460094
  • Paul, R., Jaeger, T., Abel, S., recurrence, I., Folcher, M., Biondi, EG, Laub, MT and Jenal, U. ( 2008). Allosteric regulation of histidine kinases by Their cognate response regulator deterministic mines cell fate. Cell, 133 ( 3), 452
  • Christen, M., Christen, B., Allan, MG, Folcher, M., Jeno, P., Grzesiek, S. and Jenal, U. ( 2007). DGra is a member of a new family of cyclic monophosphate receptors and controls Diguanosine flagellar motor function in Caulobacter crescentus. Proc Natl Acad Sci U S A, 104, 4112th
  • Christen, B. Christen, M., Paul, R., Schmid, F., Folcher, M., Jenoe, P., Meuwly, M. and Jenal, U. ( 2006). Allosteric control of cyclic di-GMP signaling. Journal Biological Chemistry, 281, 32015th
  • Jenal, U. and Malone, J. (2006) Mechanisms of cyclic - di-GMP signaling in bacteria. Annual Review of Genetics 40, 385
  • Christen, M., Christen, B., Folcher, M., Schauerte, A., and Jenal, U. ( 2005) Identification and characterization of a cyclic di-GMP -specific phosphodiesterase and its allosteric control by GTP. Journal Biological Chemistry, 280, 30829th
  • Paul, R., Weiser, S., Amiot, NC, Chan, C., Schirmer, T., Giese, B. and Jenal, U. ( 2004). Cell cycle- dependent dynamic localization of a bacterial response regulator with a novel di - guanylate cyclase output domain. Genes and Development, 18 (6 ), 715
  • Ackermann, M., Stearns, SC and Jenal, U. ( 2003). Senescence in a bacterium with asymmetric division. Science, 300 (5627), 1920.
Basic research Bacterial growth Pathogenic bacteria
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