Vogt–Koyanagi–Harada syndrome

The Vogt- Koyanagi -Harada syndrome is a multisystem disorder, probably a T-cell -mediated autoimmune reaction against melanocytes is based. The disease usually begins between the ages of 20 and 50 years of age and above all more pigmented populations is concerned, according to a non-specific prodromal stage that resembles a viral infection characterized by recurrent aseptic meningitis, Iridozyklitiden, vitiligo and a loss of eyelashes. The diagnostic criteria were revised in 1999. The diagnosis is made clinically, depending on the extraocular manifestations as complete, incomplete, or likely. The treatment is carried out successfully with high-dose steroids, possibly with additional long-term immunosuppressive agents such as cyclosporine. The longer-term prognosis is good for vision, when the diagnosis is made early and aggressive treatment is done.

Since 2008, an animal model of the disease exists.

The disease is named after Alfred Vogt, Yoshizo Koyanagi Harada and Einosuke. A synonym is Yuge syndrome (after T. Yuge ).