Human β-globin locus

The human β - globin locus is composed of five genes, which are located on a small region of chromosome 11, and for the formation of verantwortlch ännähernd half of the beta- parts of the oxygen -transporting protein hemoglobin. The locus includes not only the β -globin genes, but also the delta-, gamma- O -, gamma- and G- epsilon -globin. The expression of all these genes is controlled by a single locus control region (LCR) and varies during the development of these genes.

The order of the genes in the beta -globin cluster is: 5 ' - epsilon - gamma -G - gamma -A - delta - beta - 3'.

The arrangement of the genes reflects the temporal differentiation of their expression during development: The gene segment, which is important in the early embryonic stage, the LCR is the closest.