METTL3

N6 -methyl - adenosine (MT -A70 ) is an enzyme in the nucleus of all eukaryotes, the methylated at intermittent positions during the transcription, the resulting mRNA. The exact meaning of this reaction is still unclear; It is assumed that a connection with the following processes of splicing, transport from the nucleus or the translation is. In the human MT -A70 is expressed in low numbers in many tissue types.

The reaction is non- stoichiometric. Adenosine residues are preferably methylated. The normal sequence of sporulation in the brewer's yeast (Saccharomyces cerevsiae ) depends on a functioning MT -A70. In a study was METTL3 one of the genes that was upregulated in a particular cell line by use of a 50-Hz magnetic field.

Protein isoform Human Genome Organisation Methylation N6-Methyladenosine
590027
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