Phenacetin

• N-(4 - ethoxyphenyl ) ethanamid
• 1- acetamido -4- ethoxybenzene
• P- Ethoxyacetanilid
• Acetophenetidin

N02BE03

134.7 ° C

Risk

Template: Infobox chemical / molecular formula search available

Phenacetin is an aminophenol derivative and was used as a drug for the treatment of pain and fever reduction.

Phenacetin was in front of 1888 by the " factory colors. Friedr. Bayer & Co. "was introduced in Elberfeld as the first drug of the company. The raw material of p-nitrophenol was created as previously unusable by-product in large quantities in the production of dye Benzoazurin G. The third step of the acetylation was the competition product inspired Antifebrin Kalle. The trademark registration " phenacetin " was denied because other companies like the pharmaceutical factory JD Riedel OHG or Highest color works this drug also produced and sold under the name phenacetin.

It took place in numerous preparations for migraine, neuralgia and rheumatism use. Abusive it was because of its slightly euphoric effects - especially when combined with caffeine - even improve the performance of employees, eg in the watch industry, ingested. Because of its harmful, especially nephrotoxic effect in combination with other pain medications ( Phenacetinnieren or analgesic nephropathy, urothelial carcinoma ) of this drug is as a finished product ( in Germany since 1986, since 1990 in the GDR ) is no longer in trade. In Germany and other Western countries are custom-made medicines ( recipes) with phenacetin as a concern. Their preparation and delivery is therefore prohibited. Phenacetin was replaced by the metabolite paracetamol.

Phenacetin is a colorless and odorless white solid, sparingly soluble in water and melts at about 135 ° C.