Pyrophosphomevalonate decarboxylase

The Diphosphomevalonat decarboxylase ( MDDase ) is the enzyme that catalyzes the conversion of Diphosphomevalonat in most living organisms to isopentenyl diphosphate. In eukaryotes, this reaction is part of the biosynthesis of isoprenoids, especially in animals of the cholesterol biosynthesis. In human MDDase expressed in heart, lung, liver, muscle, brain, pancreas, kidney and placenta, and is located upstream, as opposed to the synthetic pathway enzymes not located in the peroxisomes, but in the cytosol.

Catalyzed reaction

ATP ADP Pi ⇒ CO2

5 - diphospho -R mevalonate is converted to isopentenyl diphosphate (IPP).

Human Genome Organisation Lyase Decarboxylation Isopentenyl pyrophosphate Digital Object Identifier
290337
de