Retinoblastoma-like protein 1

  • OMIM: 116957
  • UniProt: P28749
  • MGI: 103300

The retinoblastoma protein -like 1 ( p107, RBL1 ), a protein in eukaryotes that is involved in the regulation of cell cycle. It is directly involved in the formation of heterochromatin at the beginning of cell division by controlling chromatin structure and methylation of histones. RBL 1 is believed to be a tumor suppressor.

RBL1 / M phase transition is phosphorylated and dephosphorylated at the G1 phase of the cell cycle in S. The RB1 protein and the protein may form RBL1 to the E1A protein of adenovirus and the large T antigen of SV40 complexes. The large T - antigen binds to the RB1 and RBL1 only when they are dephosphorylated. Both proteins can inhibit the transcription of genes that govern cell cycle and have called E2F binding sites in their regulatory genes.

RBL 1 is in sequence and function to the RB1 similar. Due to the similarity that has RBL 1 with RB1, it is believed that RBL 1 is a tumor suppressor. Until now, it has found two different transcripts of the gene corresponding to two isoforms of the gene product.

Protein isoform Human Genome Organisation Mouse Genome Informatics Entrez Ensembl National Center for Biotechnology Information Adenoviridae Promoter (genetics) Pocket protein family Science (journal) Cell (journal) Oncogene (journal) Nature Genetics
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