Aniracetam

IUPAC: 1 - (4- methoxybenzoyl ) pyrrolidin- 2-one

N06BX11

Nootropics

121-122 ° C

4500 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Aniracetam (trade name: Ampamet ® ( I) Manufacturer: Menarini ) is a piracetam -like drug from the group of nootropics, which is used to changes in cognitive functions.

Representation and extraction

The drug was developed in the 70s of the last century by Hoffmann -La Roche. A synthesis starts from anisoyl chloride, which is reacted in the presence of triethylamine, with 2-pyrrolidone.

In an alternative synthesis of anisoyl chloride is first reacted with 4 -aminobutyric acid. Ring closure is then accomplished by reaction with thionyl chloride.

Chemical Properties

Aniracetam is white; it is usually as a crystalline powder before, is odorless and has a bitter taste. The solubility in water is 1.065 g / L in methanol 25 g / L, in acetonitrile, 217 g / L in chloroform 400 g / L. The melting temperature is 121.3 ° C.

Dose

The therapeutic dose is usually every day at two times 750 mg.

Possible side effects

• Dizziness
• Incoordination
• Headache
• Cognitive disorders
• Nervousness
• Vertigo