Carlo M. Croce

Carlo Maria Croce ( born December 17, 1944 in Milan ) is an Italian -born American physician who deals with cancer research and specifically genetics of cancer.

Croce studied medicine at the University La Sapienza in Rome, where he received his doctorate in 1969. From 1970 he was at the Wistar Institute of Anatomy and Biology in Philadelphia, where he was until 1988 and professor ( from 1976, of which 1980 to 1988 Wistar professor of human genetics at the University of Pennsylvania, 1987-1991 Wistar professor of pediatrics at Children's Hospital in Philadelphia ) and Deputy Director of the Institute was. 1988 to 1991 he was Director of the rock Institute for Cancer Research and Molecular Biology at Temple University and a professor of pathology and medicine, 1991-2004 Director of the Kimmel Cancer Institute at Thomas Jefferson University in Philadelphia. From 2004 he was director of the Institute of Genetics, John W. Wolfe Professor of Human Cancer Genetics and Director of the Human Cancer Genetics Program at Ohio State University. He is a board of the Department of Molecular Virology, Immunology and Medical Genetics.

In the 1970s and 1980s identified and localized at the Wistar Institute it a number of oncogenes ( BCL2, BCL1, MYC, ALL1, LATS1, FHIT ) and discovered in many leukemias and lymphomas chromosale translocations of the cause of the deregulation of oncogenes. He discovered that in CLL, the most common form of leukemia, which are micro - RNA genes miR15 and 16 disturbed in their function, the elimination of miR15 leads to increased BCL2 production. He pursued consequent approaches to drug development and developed a microRNA gene chip for diagnosis.

He has published over 680 scientific papers (2010). 1990 to 1999 he was editor of Cancer Research.

1993 Croce was awarded the Charles S. Mott Prize for Cancer Research. He is a member of the National Academy of Sciences (1996 ) and the Italian Academy of Sciences ( 2003). In 2003 he received the gold medal in Italy to the president for public health. 2000 he received the Order of Verdi Italian Republic and 1999, the Gold Medal of the city of Paris. He holds honorary doctorates from the University of Uppsala. In 2006 he received the Clowes Memorial Award from the American Association for Cancer Research for his contributions in leukemia research and the 2004 Pasarow Award ( Robert J. and Claire Pasarow Foundation). He received the Richard and Hinda Rosenthal Award, and the Pezcoller Award from the American Association for Cancer Research (AACR ), the Henry M. Stratton Medal of the American Society of Hematology, Albert Szent Gyorgyi Prize for Cancer Research and 2008 the Leopold Grifuel price. In 1994 he was made an honorary member of the Japanese Cancer Research Society and is a Fellow of the American Academy of Arts and Sciences (2010).