Chromosome 14 (human)

Chromosome 14 is one of 23 pairs of chromosomes in humans. A normal person has two nearly identical copies of this chromosome in most of its cells. Chromosome 14 is a acrocentric chromosome, that is, it has a terminal centromere.

Decryption of chromosome 14

The chromosome 14 consists of 106 million base pairs. A base pair is the smallest information unit of DNA. Chromosome 14 containing about 3 to 3.5 % of the total DNA of a human cell. The identification of the genes on this chromosome is the part of the ongoing process of the human genome. On chromosome 14 are 700-1300 genes. So far, 662 of them are known.

Known genes on chromosome 14

The chromosome 14 contains the following genes:

  • PSEN1: presenilin 1
  • Neuroglobin
  • PKB: protein kinase B
  • HIF: hypoxia induced factor
  • SRP 54: Signal recognition particle 54 kDa

Medical importance

With the genes located on chromosome 14, the following genetic diseases or symptoms are associated. These include:

  • Alpha - 1 antitrypsin deficiency
  • Alzheimer 's disease type 3
  • Burkitt's lymphoma
  • Follicular lymphoma
  • Machado - Joseph disease
  • Crohn Hers
  • Krabbe's disease
  • Multiple Myeloma
  • Niemann -Pick disease
  • Segawa syndrome
  • Senile plaques
  • Trisomy 14
  • Walker - Warburg syndrome
Cytoglobin Proteinkinase B Hypoxia-inducible factors Burkitt's lymphoma Spinocerebellar ataxia Glycogen storage disease type VI Walker–Warburg syndrome
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