Hypoxia-inducible factors

  • OMIM: 603 348
  • MGI: 106918

Hypoxia-induced factor (HIF ) is a transcription factor that regulates the supply to the cell with oxygen by establishing a balance between the oxygen demand and oxygen supply. HIF is composed of a labile α - subunit, which exists in three isoforms of HIF - 1α, HIF- 2α and HIF- 3α, and a β subunit.

With normal oxygen supply ( normoxia ) is hydroxylated the α - subunit of prolyl- specific two residues. This hydroxylation results in HIFα is degraded over the Hippel-Lindau tumor suppressor protein.

With a lack of oxygen supply ( hypoxia) is inhibited hydroxylation of HIF- α. The thus stabilized transcription factor activates the erythropoietin gene, and a number of other genes which are required to adapt the cell to an insufficient oxygen supply. Further suggest various experiments indicate HIF- induced expression of the group of growth factors Vascular endothelial growth factor (VEGF).

Protein isoform Human Genome Organisation Mouse Genome Informatics Entrez Ensembl UniProt National Center for Biotechnology Information Proline Digital Object Identifier
405095
de