Delorazepam

• 7-chloro- 5-( 2-chlorophenyl) -1,3- dihydro -1 ,4- benzodiazepin-2 (2H )-one
• Chlordesmethyldiazepam

• 940 mg · kg -1 ( LD50, mouse, oral)
• 2000 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Delorazepam is a chemical compound from the group of benzodiazepines with calming and anxiolytic activity. Chemically, it is a C- 2 ' chlorinated derivative of Nordazepams.

Of course Delorazepam comes in small amounts (100-200 ng / g) in the tarragon (Artemisia dracunculus ).

Use

Delorazepam has a long plasma half-life and is therefore mostly used as anti-anxiety agent, for example, as a premedicant in dental anxiety. Delorazepam is marketed as a drug mainly in Italy.

Pharmacology

Delorazepam has a high bioavailability and is rapidly absorbed by the body. The maximum concentration in the plasma is attained after 1-2 hours. It has a very long half-life, because even after 72 hours is still found in the blood Delorazepam. The plasma half -life varies depending on their age: in adults, it is about 97 to 100 hours in children aged 2-3 years, about 27 hours. Part of the Delorazepams is metabolized to also active lorazepam. In a ratio of 1 mg Delorazepam is approximately as effective as 10 mg of diazepam.

Delorazepam is also formed during the metabolism of the drug Cloxazolam as pharmacologically active metabolite (metabolite ).