Dereje Nedi ( born January 13, 1954) is a former Ethiopian marathon runner.
In 1978 he won silver in the marathon of the All-Africa Games. At the Olympic Games in Moscow in 1980, he was seventh.
In 1984, he won the Frankfurt Marathon and ran the Moscow Marathon with 2:10:32 at the same time personal record and the fastest time to date on Russian soil.
In 1985, he took in the African Championships bronze and 1988 gold. He was second at the IAAF World Cup Marathon and the Berlin Marathon in 1989.