Diaminopyrimidine
Diaminopyrimidine are basic organic compounds containing two amino groups on a pyrimidine ring. Depending on the arrangement of the amino groups on the ring can occur four isomers.
Use
Derivatives of diaminopyrimidines be used as pharmacological agents. They often act as folic acid antagonist, and inhibit bacterial dihydrofolate reductase. Since folic acid is an important for many bacteria and the growth- diaminopyrimidines block the synthesis of folic acid in a bacterium, to act as an antibiotic.
Representatives of this group include:
- Aminopterin
- Iclaprim
- Kopexil (used as " Aminexil " used to treat hair loss)
- Methotrexate
- Pyrimethamine
- Minoxidil ( is used to treat hair loss used )
- Trimethoprim ( main representative of the group)
- 2.5 Diaminopyrimidinnucleosidtriphosphat ( comes in the biosynthesis of biopterin from GTP ago)
The structurally similar diaminopyridine derivatives, such as 3,4- diaminopyridine, used in neurological diseases such as the Lambert-Eaton syndrome. Here is their influence on presynaptic potassium channels and over mediated increased release of transmitters used.
Related compounds
- Aminopyrimidines pyrimidines with an amino group
- Triaminopyrimidine pyrimidines with three amino groups
- Diaminopyridines pyridines with two amino groups