Fosfluconazole

• IUPAC: 2,4-difluoro- α, α -bis ( 1H-1 ,2,4-triazol- 1-ylmethyl ) benzyl alcohol, dihydrogenphosphate
• Latin: Fosfluconazolum
• UK 292 (Pfizer )
• UK 663 ( Pfizer)

J02AC

Antifungals

Template: Infobox chemical / molecular formula search available

Fosfluconazole is an antifungal agent from the group of triazoles and an ester of the antifungal fluconazole also active with phosphoric acid. It inhibits ergosterol biosynthesis.

Pharmacology

Fosfluconazole inhibits 14α -demethylase, a fungal specific cytochrome P450 isoenzyme ( CYP51A1 ), which is responsible for the conversion of lanosterol to ergosterol. Ergosterolvorstufen be incorporated into the membrane and the permeability of cell components increases.

Finished medicinal product

Prodif ( J)

There are no approvals in Germany, Austria and Switzerland.