GRIA 1

  • OMIM: 138248
  • UniProt: P42261
  • MGI: 95808

The ionotropic glutamate receptor, AMPA 1, also known as Gria1 is a human protein.

Glutamate receptors are the predominant form of the excitatory neurotransmitter receptors in the mammalian brain. They are activated by a variety of neurophysiological processes. They are composed of different subunits of heteromeric protein complexes, each of which has a transmembrane domain, and which together form a ligand-gated ion channel. The classification of glutamate receptors based on their activation by various agonists. The Gria1 belongs to the family of AMPA receptors. For each of four so-called flip- flop Grias isoforms are known that are generated by alternative splicing. The receptor subunits of the different isoforms differ in their signal transmission properties. By in situ Hybridizierung showed one that Gria1 mRNA is expressed mainly in the granule cell band and in the pyramidal cells of the hippocampus.

Protein isoform Human Genome Organisation Mouse Genome Informatics Entrez Ensembl National Center for Biotechnology Information Ulrich Mahlknecht
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