Hemangioblast

Hemangioblasts are adopted common progenitors of endothelial cells and blood cells. Therefore, they are multipotent stem cells. In the course of further differentiation are evident from the first Haemangioblasts either endothelial progenitor cells or blood cells produced, possibly hematopoietic stem cells. The latter are the starting point of blood cell formation ( hematopoiesis ).

Hemangioblasts were originally described in embryonic development, where they develop from the mesoderm and occur in the yolk sac. The current model for embryonic blood cell formation assumes that they actually exist here. In contrast, blood stem cells develop in the AGM region of the embryo not from hemangioblasts, but of special endothelial cells ( hemogenic endothelial cells ) that line the aorta.

Supported the adoption of hemangioblasts by experiments on embryonic stem cells in their differentiation precursor cells were found that had both hematopoietic and endothelial potential for development. For these BL- CFC ( blast colony-forming cell) mentioned cells also vascular smooth muscle cells could be generated.

There are indications that hemangioblasts also occur in adult individuals.

The existence of hemangioblasts was first proposed in 1874 by Louis -Antoine Ranvier.

Hemangioblasts are not the affected cells in a hemangioblastoma, a tumor, starting from the differentiated cells to proliferate.

Swell

• Cell type
• Hematology